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[Hashimoto encephalopathy: steroid-sensitive encephalopathy in Hashimoto thyroiditis].
M Hartmann1, B Schaner, K Scheglmann
1Neurologische Klinik, Zentralklinikum Augsburg.
Der Nervenarzt
|August 5, 2000
Summary
Hashimoto's encephalopathy, a neurological disorder linked to Hashimoto's thyroiditis, presents with confusion and seizures. Steroid treatment effectively manages this condition, as shown in two patient cases.
Area of Science:
- Neurology
- Endocrinology
- Immunology
Background:
- Hashimoto's encephalopathy is a rare neurological condition.
- It is characterized by relapsing or progressive encephalopathy.
- It is associated with Hashimoto's thyroiditis, an autoimmune thyroid disorder.
Observation:
- Two cases of Hashimoto's encephalopathy in 55- and 77-year-old patients are presented.
- Clinical features included confusion, seizures, altered consciousness, and stroke-like episodes.
- Typical findings were elevated cerebrospinal fluid protein without increased white blood cells and abnormal EEG.
Findings:
- Both patients demonstrated significant improvement following steroid therapy.
- Neuroimaging studies (CT, MRI) and cerebral angiograms were unremarkable in these cases.
- The condition is steroid-responsive, indicating an inflammatory or autoimmune basis.
Implications:
- This highlights the importance of considering Hashimoto's encephalopathy in patients with unexplained neurological symptoms and thyroid autoimmunity.
- Prompt steroid treatment can lead to favorable outcomes.
- Further research into the underlying mechanisms is warranted to optimize therapeutic strategies.