Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Axonal involvement in multiple sclerosis. Current concepts].

B Casanova-Estruch1, F Coret-Ferrer, L Landete

  • 1Servicio de Neurología, Hospital Universitari La Fe, Valencia, España. bcasanovae@meditex.es

Revista De Neurologia
|August 5, 2000
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Relevance of serum neurofilament light chain determination as a biomarker in multiple sclerosis. Consensus of the Spanish Society of Neurology's Study Group on Multiple Sclerosis and Related Neuroimmune Diseases.

Neurologia·2026
Same author

Recommendations for the critical reading of clinical trials on disease-modifying drugs for multiple sclerosis.

Neurologia·2025
Same author

[XVI Post-ECTRIMS Meeting: review of the new developments presented at the 2023 ECTRIMS Congress (II)].

Revista de neurologia·2024
Same author

[XVI Post-ECTRIMS Meeting: review of the new developments presented at the 2023 ECTRIMS Congress (I)].

Revista de neurologia·2024
Same author

[15th Post-ECTRIMS Meeting: a review of the latest developments presented at the 2022 ECTRIMS Congress (Part II)].

Revista de neurologia·2023
Same author

[15th Post-ECTRIMS Meeting: a review of the latest developments presented at the 2022 ECTRIMS Congress (Part I)].

Revista de neurologia·2023
Same journal

<sup>18</sup>F-FDG PET/MRI Multiparametric Imaging Features for Predicting MYCN Amplification Status in Children With High-Risk Neuroblastoma.

Revista de neurologia·2026
Same journal

Anti-Melanoma Differentiation-Associated Gene 5 Antibody-Positive Juvenile Dermatomyositis Presenting With Predominant Joint Contractures.

Revista de neurologia·2026
Same journal

Association Between Immunotherapy and Generalization in Ocular Myasthenia Gravis as a Function of Antibody Status.

Revista de neurologia·2026
Same journal

Systematic Review and Meta-Analysis of the Efficacy of Fecal Microbiota Transplantation in Parkinson's Disease: An Exploration Based on UPDRS and Cognitive Scores.

Revista de neurologia·2026
Same journal

EEG Quantification: A New Dawn for an Old Tool.

Revista de neurologia·2026
Same journal

The Dual Role of VEGF in Intracerebral Haemorrhage: From Pathological Mechanisms to Therapeutic Opportunities.

Revista de neurologia·2026
See all related articles

Axon damage is central to multiple sclerosis (MS) pathology, occurring early in demyelination. Understanding axonal lesions offers a new physiopathogenic concept for MS, better aligning with clinical and pathological findings.

Area of Science:

  • Neuroscience
  • Pathology
  • Immunology

Context:

  • Multiple sclerosis (MS) is increasingly recognized to involve early and significant axon pathology.
  • Axonal damage is a key feature, present from the earliest stages of demyelinating plaque development.
  • This damage is supported by extensive clinical, radiological, and pathological evidence.

Purpose:

  • To explore the role of axon pathology in multiple sclerosis.
  • To examine the interplay between axonal damage and the inflammatory response in MS.
  • To identify parameters for measuring axonal damage and its correlation with disability.

Summary:

  • Axon pathology is a fundamental aspect of multiple sclerosis (MS), manifesting early in the disease course.
  • The article reviews how axons are affected in MS, influencing inflammation and disability.

Related Experiment Videos

  • A novel physiopathogenic concept of MS centered on axonal lesions is proposed, enhancing current clinico-pathological understanding.

    • Impact:

    • Highlights the critical role of axons in MS pathogenesis.
    • Provides a framework for understanding MS disability progression.
    • Suggests a paradigm shift towards an axon-centric view of multiple sclerosis.