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Increased HLA-DR homozygosity associated with pre-eclampsia.

I de Luca Brunori¹, L Battini, M Simonelli

¹Department of Reproductive Medicine and Child Development, Stella Maris Foundation and Institute of Immunohematology, University of Pisa, S. Chiara Hospital, Italy. g.arcidiacono@obgyn.med.unipi.it

Human Reproduction (Oxford, England)

|August 2, 2000

Summary

Maternal recognition of fetal antigens is crucial for pregnancy. This study found that human leukocyte antigen (HLA)-DR homozygosity and reduced antigen sharing between couples significantly increase pre-eclampsia risk.

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Area of Science:

Immunogenetics
Reproductive Immunology
Obstetrics

Background:

Maternal recognition of paternally derived fetal antigens is vital for successful pregnancy.
Human leukocyte antigen (HLA) class II DR antigens play a key role in immune recognition.

Purpose of the Study:

To investigate the association between HLA-DR antigens and pre-eclampsia in women and their partners.
To determine if HLA-DR homozygosity or compatibility influences pre-eclampsia risk.

Main Methods:

Serological Terasaki technique used to test HLA-DR antigens.
Study included 70 pre-eclamptic primigravidae women and their partners, and 70 healthy control couples.

Main Results:

No specific HLA-DR antigen was correlated with pre-eclampsia.

Related Experiment Videos

Significant increase in HLA-DR homozygosity observed in pre-eclamptic women and their partners (67.1% vs 7.9% in controls).

Increased female-to-male and male-to-female HLA-DR compatibility found in pre-eclamptic couples compared to controls.

Conclusions:

HLA-DR homozygosity and reduced antigenic disparity between partners are associated with an increased risk of pre-eclampsia.
Pre-eclampsia may be considered a 'couple's disease' due to the immunological relationship between partners.