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The hypocretin/orexin story.

W K Samson1, Z T Resch

  • 1Department of Pharmacological and Physiological Sciences, Saint Louis University School of Medicine, 1402 South Grand Boulevard, St Louis, MO 63131, USA. samsonwk@slu.edu

Trends in Endocrinology and Metabolism: TEM
|August 2, 2000
PubMed
Summary

Newly discovered peptides, hypocretins/orexins, stimulate appetite and regulate arousal states. These lateral hypothalamic peptides also influence autonomic functions and neuroendocrine effects, impacting sleep-wakefulness.

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Area of Science:

  • Neuroscience
  • Endocrinology
  • Physiology

Background:

  • Neurons in the lateral hypothalamic area produce newly identified peptides.
  • These peptides, hypocretins/orexins, were discovered independently by two research groups.
  • They are known to stimulate appetite and feeding-related behaviors.

Purpose of the Study:

  • To investigate the role of hypocretins/orexins in regulating physiological functions.
  • To explore the neuroendocrine and metabolic effects of these peptides.
  • To understand their involvement in arousal and sleep-wakefulness states.

Main Methods:

  • Peptide identification and characterization.
  • Behavioral studies in animal models.
  • Neuroendocrine and autonomic function assessments.

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Main Results:

  • Hypocretins/orexins stimulate appetite and stereotypic feeding behaviors.
  • These peptides are physiological regulators of the arousal state.
  • Emerging evidence points to their role in neuroendocrine and metabolic functions, including sleep-wakefulness.

Conclusions:

  • Hypocretins/orexins are key regulators of appetite and arousal.
  • Further research is needed to fully elucidate their complex neuroendocrine and metabolic roles.
  • These peptides represent a significant discovery in understanding homeostatic regulation.