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[Histopathological study of local invasiveness of transglottic cancer]
1Department of Otolaryngology, First Affiliated Hospital, China Medical University, Shenyang.
Objective:
To explore the characteristics and relevant factors of transglottic cancer invading paraglottic space (PGS) and pre-epiglottic space (PES).
Methods:
Whole-organ serial sections of 50 transglottic cancer specimens were studied histopathologically.
Results:
Transglottic cancer invading PGS was observed in 39 of the 50 (78.0%) specimens. In 32 of the 39 specimens, the invasion outstripped PGS, involving elastic cone in 26(81.3%), thyroid cartilage in 24(75.0%) and cricothyroid membrane in 20(62.5%). Transglottic cancer invading PES was seen in 23 of the 50 specimens (46.0%). With the increase in tumor staging and tumor size, PGS and PES became increasingly invaded. There were two possible routes of invasion to PES: a) extending anteriorly and upward via PGS; b) extending upward via anterior commissure to destroy the stem of epiglottic cartilage.
Conclusion:
PGS is easily invaded by transglottic cancer. Partial laryngectomy is recommended in patients with T3, T4 transglottic cancer larger than 20 mm in diameter.