[An experimental study of auto-allergy evoked by staphylococcus under conditions of primary and secondary...

Experiments were conducted on rabbits and albino mice; it was shown that the capacity of the animal organism to reject the skin autotransplant formed 7 to 10 days after the primary immunization and persisted for a period of 45 days. Repeated vaccination of mice 24 hours before the operation aided the take of the skin autotransplants, and 7 days before--promoted their rejection. Intravenous revaccination of the operated animals also intensified the rejection reactions; the process of the transplant rejection was accompanied by a marked fall in the level of staphylococcus- and autoantibodies. In the unoperated animals intravenous revaccination with staphylovaccine caused production of antibodies by the secondary type. Deposits of fixed gamma-globulin were found on the 6th-8th day after the transplantation in the autotransplant and its bed in mice primarily immunized with staphylovaccine. Marked circulatory disturbances, necrobiotic processes, mononuclear infiltration of the derma with neutrophils were revealed pathomorphologically in the rejecting skin transplant.