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[The relationship between hepatocellular carcinoma and hepatitis C virus infection in Guangxi, China]
Objective:
To study the significance of HCV infection as a risk factor for hepatocellular carcinoma (HCC) in Guangxi.
Methods:
Monoclonal antibodies against the core, NS3 and NS4 region of HCV, and anti-HBsAg antibody were used for immunohistochemical staining.
Results:
The frequency of HCV infection from regions with high, intermediate and low prevalence of HCC was 24/63(38.1%), 23/62 (37.1%) and 30/77(39.0%), respectively, while that of HBsAg was 84.1%, 83.8% and 84.4%, respectively. The overall positive rate of HCV infection was 77/202 (38.1%), and of HBV infection was 170/202 (84.2%).
Conclusion:
While HBV infection frequently accompanies HCC, HCV infection is present in more than 1/3 of HCC. This is generally the case regardless of geographical difference in HCC prevalence.