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[Normal-sized ovary carcinoma syndrome--clinical and pathological analysis of 11 cases]
1Department of Gynecological Oncology and Pathology, Cancer Institute(Hospital), Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing.
Objective:
To evaluate clinical-pathologic features, diagnostic criteria, effective treatment and prognosis of a clinically rare "normal-sized ovary carcinoma syndrome".
Methods:
Histologic slides of 11 cases from 1984 to 1993 of normal-sized ovary carcinoma syndrome were retrospectively reviewed. Seven of the 11 cases were extraovarian peritoneal serous papillary carcinoma (EPSPC). The remaining 4 cases were serous adenocarcinoma of the ovary (2 cases), malignant mesothelioma (1 case) and metastatic poorly differentiated adenocarcinoma of unknown origin (1 case). All patients received relatively thorough surgical resection combined with multiple courses of adjuvant chemotherapy.
Results:
The patient with malignant mesothelioma survived for 90 months, one case with EPSPC survived for 87 months up to Dec 1997. The average survival time of 9 patients who died of their diseases was 17.8 months, being longer than that reported in the literature.
Conclusion:
Following accurate diagnosis of normal-sized ovary carcinoma syndrome, radical tumor resection is the first treatment of choice. For residual tumor, postoperative chemotherapy or radiotherapy is essential to obtain better prognosis.