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High-throughput Quantitative Real-time RT-PCR Assay for Determining Expression Profiles of Types I and III Interferon Subtypes
Published on: March 24, 2015
[Study on expression of IRF-1 gene in human leukemia with RT-PCR and the silver sequence techniques]
Zhonghua Xue Ye Xue Za Zhi = Zhonghua Xueyexue Zazhi
|August 2, 2000
Abstract
Objective:
To explore preliminarily the changes of IRF-1 gene expression in leukemias.
Methods:
The expression of IRF-1 gene in 24 leukemia patients and 3 leukemic cell lines were studied with RT-PCR and the silver sequence techniques.
Results:
No expression of IRF-1 gene in 3 patients, and significantly decreased expressions in 5 patients and in HL-60 and HIMeg cell lines were revealed.
Conclusion:
The mechanism of human leukemogenesis may be partly associated with no or low-expression of IRF-1 gene.
