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[Squamous cell type lung cancer that produced granulocyte colony-stimulating factor]
R Hirokawa1, S Fujino, S Inoue
1Second Department of Surgery, Shiga University of Medical Science, Japan.
Summary
This study reports a rare case of squamous cell lung cancer that produced granulocyte-colony stimulating factor (G-CSF). This G-CSF production explained the patient's elevated white blood cell and platelet counts.
Area of Science:
- Oncology
- Pulmonary Medicine
- Endocrinology
Background:
- Lung cancer, particularly squamous cell carcinoma, can present with paraneoplastic syndromes.
- Granulocyte-colony stimulating factor (G-CSF) is a cytokine that stimulates white blood cell production.
Observation:
- A 73-year-old male presented with weight loss, fever, leukocytosis, thrombocytosis, and elevated C-reactive protein (CRP).
- Imaging revealed a right upper lobe lung mass with mediastinal pleural invasion, diagnosed as T3N0M0 stage IIB squamous cell carcinoma.
- Preoperative serum G-CSF levels were significantly elevated (234 pg/ml) and decreased postoperatively (68.8 pg/ml).
Findings:
- Tumor cells stained positive for G-CSF, and no infectious agents were detected.
- Post-surgery, the patient's leukocytosis, thrombocytosis, and CRP normalized, and fever resolved.
- This confirmed a diagnosis of G-CSF-producing squamous cell lung cancer.
Implications:
- This case highlights a rare paraneoplastic syndrome caused by G-CSF-producing lung cancer.
- Understanding this mechanism is crucial for accurate diagnosis and management of similar cases.
- Further research may explore targeted therapies for G-CSF-producing tumors.