Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Multiple endocrine neoplasia type 2; MEN 2].

K Matsuura1, K Araki

  • 1Department of Surgery, Kochi Medical School.

Nihon Rinsho. Japanese Journal of Clinical Medicine
|August 2, 2000
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Stromal sarcoma of the breast with lung metastasis successfully treated by radiotherapy: report of a case.

Surgery today·2001
Same author

Thin molecular films of supramolecular porphyrins.

Anais da Academia Brasileira de Ciencias·2000
Same author

Involvement of inhibin in the regulation of follicle-stimulating hormone secretion in the young adult male Shiba goat.

Journal of andrology·2000
Same author

A boy with normal growth in spite of growth hormone deficiency after resection of a suprasellar teratoma.

Endocrine journal·2000
Same author

Infantile convulsions with mild gastroenteritis.

Brain & development·2000
Same author

Detection of hantaviral antibodies among patients with hepatitis of unknown etiology in Japan.

Microbiology and immunology·2000
Same journal

[Development of novel therapeutics for multiple myeloma and improvement of drug lag].

Nihon rinsho. Japanese journal of clinical medicine·2019
Same journal

[Clinical pharmacy services to patients of immunomodulatory drugs].

Nihon rinsho. Japanese journal of clinical medicine·2019
Same journal

[Therapeutic drug monitoring of the new anti-myeloma drugs in the treatment of multiple myeloma].

Nihon rinsho. Japanese journal of clinical medicine·2019
Same journal

[Prognostic value of minimal residual disease assessment using next-generation sequencing in multiple myeloma].

Nihon rinsho. Japanese journal of clinical medicine·2019
Same journal

[The evaluation of minimal residual disease in multiple myeloma by an allele-specific oligonucleotide real-time PCR].

Nihon rinsho. Japanese journal of clinical medicine·2019
Same journal

[Evaluation of minimal residual disease in myeloma by multiparametric flow cytometry].

Nihon rinsho. Japanese journal of clinical medicine·2019
See all related articles

Multiple endocrine neoplasia type 2 (MEN 2) is an inherited disorder characterized by medullary thyroid carcinoma (MTC). Genetic testing for RET proto-oncogene mutations enables early diagnosis and treatment of MEN 2 subtypes.

Area of Science:

  • Endocrinology
  • Genetics
  • Oncology

Background:

  • Multiple endocrine neoplasia type 2 (MEN 2) is an autosomal dominant inherited disorder.
  • It is characterized by medullary thyroid carcinoma (MTC) and classified into MEN 2A, MEN 2B, and familial MTC.
  • Germline mutations in the RET proto-oncogene are associated with MEN 2.

Purpose of the Study:

  • To review the classification, clinical features, RET mutations, and management of MEN 2.
  • To discuss recent research on the molecular basis of MEN 2.
  • To explore the role of genetic testing in clinical management for affected individuals and at-risk families.

Main Methods:

  • Review of existing literature on MEN 2.
  • Analysis of RET proto-oncogene mutations.

Related Experiment Videos

  • Discussion of genetic testing strategies.

    • Main Results:

    • MEN 2 subtypes are linked to specific RET proto-oncogene mutations.
    • Genetic testing facilitates early diagnosis of presymptomatic carriers.
    • Early surgical intervention is crucial for managing MEN 2.

    Conclusions:

    • Understanding the molecular basis of MEN 2 is key for effective management.
    • Genetic testing is a vital tool for early detection and intervention in MEN 2.
    • Personalized clinical management strategies can be developed based on genetic findings.