Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Werner syndrome].

M Goto1, Y Ishikawa

  • 1Dept. of Rheumatology, Tokyo Metropolitan Otsuka Hospital.

Nihon Rinsho. Japanese Journal of Clinical Medicine
|August 2, 2000
PubMed
Summary
This summary is machine-generated.

Werner syndrome (WS) patients exhibit a higher incidence of rare cancers, particularly sarcomas and thyroid carcinoma. Understanding the WRN gene

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A novel orally active inhibitor of IL-1 generation: synthesis and structure-activity relationships of 3-(4-hydroxy-1-naphthalenyl)-2-propenoic acid derivatives.

Journal of medicinal chemistry·1992
Same author

Atrial contractility affects phasic blood flow velocity of atrial small vessels in the dog.

Cardiovascular research·1992
Same author

Early metabolic effects of sepsis in the preterm infant: lactic acidosis and increased glucose requirement.

The Journal of pediatrics·1992
Same author

Isolation of kinesin from rat liver.

Gastroenterologia Japonica·1992
Same author

Regulation of differentiation and proliferation of rat hepatocytes by lactose-carrying polystyrene.

Artificial organs·1992
Same author

In vitro susceptibility of clinical isolates of Bacteroides fragilis and Bacteroides thetaiotaomicron in Japan.

European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology·1992

Area of Science:

  • Genetics
  • Oncology
  • Molecular Biology

Background:

  • Werner syndrome (WS) is linked to an increased risk of unusual cancers, notably sarcomas.
  • Thyroid carcinoma is the most common epithelial cancer in WS patients, representing 14% of neoplasia in Japanese individuals with WS.
  • The ratio of epithelial to non-epithelial cancers in WS patients is 1:1, contrasting with the 10:1 ratio in the general adult population.

Purpose of the Study:

  • To investigate the genetic and molecular underpinnings of cancer predisposition in Werner syndrome.
  • To explore genotype/phenotype correlations in WS-associated cancers, considering site-specific mutations or host susceptibility factors.
  • To elucidate the role of the WRN gene and its protein product in aging and cancer development.

Main Methods:

Related Experiment Videos

  • Identification of the Werner syndrome gene (WRN) as a RecQ type DNA/RNA helicase located on chromosome 8p12.
  • Characterization of the wild-type WRN protein's DNA helicase activity.
  • Functional studies of the WRN helicase to understand its role in aging and cancer.

    • Main Results:

    • The WRN gene encodes a RecQ type DNA/RNA helicase.
    • The wild-type WRN protein possesses DNA helicase activity, essential for unwinding DNA/RNA duplexes.
    • WS is associated with a significantly altered cancer spectrum, including a higher proportion of non-epithelial cancers.

    Conclusions:

    • The WRN gene and its helicase activity are crucial in the context of aging and cancer.
    • Further functional studies of the WRN helicase may provide insights into the mechanisms of aging and cancer.
    • Understanding WRN's role could lead to novel therapeutic strategies for WS-associated cancers.