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Immune response to Escherichia coli.

W B Gross, P B Siegel

American Journal of Veterinary Research

|April 1, 1975

Summary

Chickens bred for low plasma corticosterone (LPC) showed better vaccine response and growth, while those bred for high plasma corticosterone (HPC) exhibited stronger resistance to bacterial infections like E. coli.

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Area of Science:

Animal Science
Immunology
Genetics

Background:

Plasma corticosterone levels in chickens can be influenced by artificial selection.
Understanding the implications of selected corticosterone levels on immune function is crucial for poultry health.
Differences in immune response and disease resistance may exist between lines selected for high (HPC) and low (LPC) plasma corticosterone.

Purpose of the Study:

To compare the immune response and disease resistance between chicken lines selected for high and low plasma corticosterone.
To evaluate the impact of plasma corticosterone levels on antibody production, growth, and resistance to bacterial challenge.

Main Methods:

Artificial selection was used to establish distinct chicken lines with high (HPC) and low (LPC) plasma corticosterone levels.
Immune response was assessed by measuring antibody titers, onset, and duration of production following antigen exposure.
Body weight gain and resistance to Escherichia coli challenge were evaluated in both selected lines.

Main Results:

The LPC line demonstrated superior antibody production (higher titers, earlier onset, longer duration) and greater body weight gain compared to the HPC line.
The HPC line exhibited enhanced resistance to Escherichia coli challenge and antigen compared to the LPC line.
LPC chickens responded effectively to lower antigen dosages, indicating a potentially more responsive adaptive immune system to vaccination.

Conclusions:

Artificial selection for low plasma corticosterone in chickens enhances vaccine-mediated immunity and growth performance.
Conversely, selection for high plasma corticosterone confers greater natural resistance to bacterial infections.
These findings suggest distinct advantages for each line, with LPC chickens benefiting more from vaccination and HPC chickens showing better innate defense against pathogens.

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