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Identification of Intracellular Signaling Events Induced in Viable Cells by Interaction with Neighboring Cells Undergoing Apoptotic Cell Death
09:18

Identification of Intracellular Signaling Events Induced in Viable Cells by Interaction with Neighboring Cells Undergoing Apoptotic Cell Death

Published on: December 27, 2016

Role and regulation of apoptotic cell death in the kidney. Y2K update

A Ortiz1, C Lorz, M P Catalan

  • 1Division of Nephrology. Fundacion Jimenez Diaz, Madrid, Spain. aortiz@fjd.es

Frontiers in Bioscience : a Journal and Virtual Library
|August 3, 2000
PubMed

Insights

Apoptosis, or programmed cell death, is crucial for regulating cell numbers and is implicated in renal diseases. Understanding its molecular regulators offers insights into kidney injury and potential treatments.

Area of Science:

  • Molecular Biology
  • Cell Biology
  • Nephrology

Background:

  • Apoptosis balances mitosis to control cell number, essential for tissue homeostasis.
  • Abnormalities in cell number are common in various renal diseases.
  • The molecular mechanisms of apoptosis are complex, involving extracellular and intracellular factors.

Purpose of the Study:

  • To review current concepts on the molecular regulation of apoptotic cell death.
  • To discuss the role of apoptosis in the development and resolution of renal injury.
  • To summarize the expression and function of apoptosis regulatory proteins in renal syndromes.

Main Methods:

  • Literature review of current concepts in apoptosis.
  • Analysis of the influence of extracellular survival and lethal factors.
  • Examination of intracellular regulators including death receptors, Bcl-2 family proteins, mitochondria, and caspases.

Main Results:

  • Apoptosis is regulated by a network of extracellular signals and intracellular proteins.
  • Specific apoptosis regulatory proteins are expressed and functional in various renal syndromes.
  • Apoptosis plays a significant role in the pathogenesis, progression, and resolution of renal injury.

Conclusions:

  • A comprehensive understanding of apoptosis molecular regulation is vital for nephrology.
  • Targeting apoptosis pathways presents potential therapeutic strategies for renal diseases.
  • Further research into apoptosis regulatory proteins in renal syndromes is warranted for clinical intervention.

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