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[Synthesis and antioxidant activity of azole derivatives of hemin]
E A Rozhkova1, A I Lysko, K V Kuleshov
1Lomonosov State Academy of Fine Chemical Technology, Moscow, Russia. e_rozhkova@yahoo.com
Bioorganicheskaia Khimiia
|August 3, 2000
Abstract:
New derivatives of proto- and deuterohemin IX containing tri- and tetrazole rings were synthesized and characterized. A pronounced antioxidant activity was found for these compounds in the Fe(II)/ascorbate-dependent system of lipid peroxidation in murine liver homogenates.