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[P16 expression in lung cancer and its significance]
Zhonghua Yi Xue Za Zhi
|August 3, 2000
Abstract
Objective:
To study the relationship of suppressor gene p16 and lung cancer for prognosis evaluation.
Methods:
Immunohistochemical method was used to detect and analyse the expression of P16 protein of CDKN2 suppressor gene of 76 cases in formalin-fixed, paraffin-embedded tissue specimens of human lung cancer.
Results:
P16 positive rate was 45%: 52% for 23 of 44 cases of squamous carcinoma and 29% for 7 of 24 cases of adenocarcinoma. Differentiation degree and prognosis of lung cancer were associated significantly with P16 expression. P16 expression was somewhat related to clinical stage.
Conclusion:
P16 gene plays a key role in the prognosis of patients with lung cancer.