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Acquired angioedema associated with sinusitis.

R D Watson1, M E Gershwin

  • 1Allergy Department, Medical Clinic of Sacramento, USA.

Journal of Investigational Allergology & Clinical Immunology
|August 3, 2000
PubMed
Summary
This summary is machine-generated.

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This study suggests a link between chronic sinusitis and angioedema. Treating sinusitis significantly improved angioedema symptoms in patients, indicating a potential causal relationship for this condition.

Area of Science:

  • Otolaryngology
  • Allergy and Immunology
  • Dermatology

Background:

  • Sinusitis is a common condition, often associated with asthma and Wegener's granulomatosis.
  • Angioedema is a potentially life-threatening condition that can be difficult to diagnose.
  • The relationship between sinusitis and angioedema is not well-established.

Observation:

  • Nine patients with recurrent angioedema, excluding known causes, were treated for chronic sinusitis.
  • Only three patients presented with overt symptoms of a sinus infection.
  • Computed tomography (CT) scans revealed occult sinusitis in most patients.

Findings:

  • All nine patients experienced significant improvement in angioedema after sinusitis treatment.
  • No further severe angioedema episodes occurred in the treated patients.

Related Experiment Videos

  • Mild angioedema episodes, when they recurred, were linked to sinusitis and responded to antibiotics.

    • Implications:

    • The findings suggest a causal link between chronic sinusitis and idiopathic angioedema.
    • Investigating sinusitis may be crucial for patients with unexplained angioedema.
    • Sinusitis evaluation may also benefit patients with chronic urticaria.