Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Nerve excitability--toward an integrating concept.

E Neumann, D Nachmansohn

    Biomembranes
    |January 1, 1975
    PubMed
    Summary

    This study proposes an integral model for nerve excitability, focusing on acetylcholine translocation through basic excitation units in membranes. This physicochemical theory explains nerve impulse generation and propagation via a cooperative increase in cholinergic system activity.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    On The Physiological Significance of Choline Esterase.

    The Yale journal of biology and medicine·2011
    Same author

    On the permeability of the nerve axon to diisopropyl fluorophosphate.

    Federation proceedings·2010
    Same author

    On the rôle of acetylcholine during nerve activity.

    Federation proceedings·2010
    Same author

    Chemical aspects of the transmission of nerve impulses.

    Progress in neurology and psychiatry·2010
    Same author

    On the energy source of the action potential in the electric organ of Electrophorus electricus.

    The Journal of biological chemistry·2010
    Same author

    Effects of inhibitors of choline esterase on the nerve action potential.

    Journal of neurophysiology·2010

    Area of Science:

    • Bioelectricity
    • Neuroscience
    • Membrane Biophysics

    Background:

    • The precise mechanism of nerve excitability remains incompletely understood despite extensive research.
    • Existing models often provide partial explanations, failing to integrate diverse experimental findings.
    • Previous attempts at integral interpretations laid groundwork for a quantitative physicochemical theory.

    Purpose of the Study:

    • To advance a quantitative physicochemical theory of bioelectricity and nerve excitability.
    • To explore the concept of a basic excitation unit within excitable membranes.
    • To model sub- and suprathreshold responses using kinetic parameters of membrane processes.

    Main Methods:

    • Integration of electrophysiological, biochemical, and biophysical data.
    • Exploration of a basic excitation unit model for excitable membranes.
    • Application of a chemical hypothesis for bioelectricity control, incorporating acetylcholine processing.

    Main Results:

    • The integral model successfully incorporates experimental facts on acetylcholine-processing proteins.
    • Acetylcholine ions are proposed to translocate continuously through basic excitation units.
    • Nerve impulse generation and propagation are linked to cooperative increases in acetylcholine translocation.

    Conclusions:

    • The proposed integral model offers a comprehensive physicochemical explanation for nerve excitability.
    • The basic excitation unit and acetylcholine translocation are central to nerve impulse dynamics.
    • This model provides a framework for understanding threshold behavior and strength-duration curves.

    Related Experiment Videos