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Updated: Aug 19, 2026

Cell Population Analyses During Skin Carcinogenesis
Published on: August 21, 2013
Actinic keratosis is squamous cell carcinoma
1Division of Dermatology and Cutaneous Surgery, University of South Florida, Tampa, USA.
Background:
The prevalence of nonmelanoma skin cancer in the United States is alarming. It can be most appropriately treated if the earliest manifestation of cutaneous squamous cell carcinoma is recognized.
Methods:
Clinical, histologic, and molecular biology, considerations were reviewed to determine whether actinic keratosis is the earliest clinical manifestation of cutaneous squamous cell carcinoma.
Results:
The clinical, histologic, and molecular parameters of actinic keratosis are those of squamous cell carcinoma.
Conclusion:
Actinic keratosis does not transform, convert, or progress into cutaneous squamous cell carcinoma but is the earliest clinically recognizable manifestation of this malignancy.
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