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Related Experiment Videos

Phenotypic screening for heart rate variability in the mouse.

J Gehrmann1, P E Hammer, C T Maguire

  • 1Department of Cardiology, Children's Hospital-Boston, and Department of Pediatrics, Harvard Medical School, Boston, Massachusetts 02115, USA.

American Journal of Physiology. Heart and Circulatory Physiology
|August 3, 2000
PubMed
Summary

We developed a new technology for analyzing heart rate (HR) variability in mice, aiding the study of cardiac electrical diseases and autonomic nervous system function.

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Area of Science:

  • Cardiovascular Physiology
  • Neuroscience
  • Animal Models

Background:

  • Mice are crucial animal models for understanding biological processes and cardiac electrical diseases due to available gene mutations.
  • Advancing research requires better methods for analyzing mouse cardiovascular physiology and autonomic regulation.
  • Understanding heart rate dynamics is key to characterizing cardiac function in disease models.

Purpose of the Study:

  • To develop and present a technology for heart rate variability (HRV) analysis in mice.
  • To characterize heart rate dynamics modulated by vagal and sympathetic activity.
  • To enable functional analysis of mouse cardiovascular physiology for disease research.

Main Methods:

  • Utilized telemetric techniques for continuous heart rate monitoring in mice.

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  • Computed standard time and frequency-domain measures of HRV.
  • Performed autonomic blockade and baroreflex sensitivity testing to assess autonomic control.

    • Main Results:

    • Demonstrated that high-frequency HRV components are primarily influenced by the parasympathetic nervous system.
    • Showed that low-frequency HRV components are modulated by both parasympathetic and sympathetic systems.
    • Validated the technology for assessing autonomic regulation of murine heart rate.

    Conclusions:

    • The developed technology and protocol provide a robust method for assessing autonomic regulation of heart rate in mice.
    • This approach enhances the utility of mice as models for heritable human electrophysiological diseases.
    • Facilitates phenotypic screening for heart rate regulation, advancing cardiovascular research.