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Related Experiment Videos

Prolactin studies in "functionless" pituitary tumours.

D F Child, S Nader, K Mashiter

    British Medical Journal
    |March 15, 1975
    PubMed
    Summary
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    Hyperprolactinemia, linked to enlarged sella turcica and hypogonadism, was common in women. Bromocriptine treatment effectively lowered prolactin levels in most patients.

    Area of Science:

    • Endocrinology
    • Neuroendocrinology
    • Radiology

    Background:

    • Hyperprolactinemia is a condition characterized by elevated prolactin levels.
    • Hypogonadism, a state of reduced gonadal function, can be associated with endocrine disorders.
    • A radiologically enlarged sella turcica may indicate pituitary abnormalities.

    Purpose of the Study:

    • To investigate the clinical and radiological features of patients with hyperprolactinemia, hypogonadism, and enlarged sella turcica.
    • To assess the effect of bromocriptine treatment on hyperprolactinemia.
    • To evaluate luteinizing hormone (LH) levels and responsiveness to LH-releasing hormone (LHRH) in these patients.

    Main Methods:

    • Clinical assessment of 17 women and 6 men with hypogonadism and enlarged sella turcica.

    Related Experiment Videos

  • Measurement of serum prolactin levels.
  • Radiological evaluation of the sella turcica using tomography.
  • Bromocriptine administration and monitoring of prolactin suppression.
  • Assay of basal LH levels and LH response to LHRH stimulation.
  • Pituitary biopsy and microscopic examination.

    • Main Results:

    • Hyperprolactinemia was present in all 17 women and 1 of 6 men.
    • A positive correlation was observed between prolactin levels and sella turcica size, with exceptions in two patients.
    • Bromocriptine effectively suppressed hyperprolactinemia in most patients.
    • Low basal LH levels were found in 9 of 18 patients, and 8 of 12 showed subnormal LH response to LHRH.
    • Pituitary biopsies revealed acidophil granules in some cases.

    Conclusions:

    • Hyperprolactinemia is a significant finding in patients with hypogonadism and enlarged sella turcica.
    • Bromocriptine is an effective treatment for hyperprolactinemia in this cohort.
    • The findings suggest a potential link between pituitary pathology, hyperprolactinemia, and altered gonadotropin secretion.