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Matemone, a new bioactive bromine-containing oxindole alkaloid from the indian ocean sponge Iotrochota purpurea
I Carletti1, B Banaigs, P Amade
1LPTE, Faculté des Sciences, Université de Nice Sophia-Antipolis, 28 Avenue de Valrose, 06108 Nice-Cedex 2, France.
Abstract:
A new bioactive bromine-containing oxindole alkaloid, matemone (1), was isolated from the Indian Ocean sponge Iotrochota purpurea, together with the known 6-bromoindole-3-carbaldehyde. The structures were elucidated on the basis of spectral and chemical data. Compound 1 shows mild cytotoxicity against three cancer cell lines and marginal antibacterial activity against Staphyloccocus aureus. DNA intercalant screening demonstrated DNA interactions with 1. Both compounds inhibit division of sea-urchin eggs.
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