Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Oral reading in dementia.

K Noble1, G Glosser, M Grossman

  • 1Department of Neurology, University of Pennsylvania, Philadelphia 19104-4283, USA.

Brain and Language
|August 5, 2000
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Downstream effects of polypathology on neurodegeneration of medial temporal lobe subregions.

Acta neuropathologica communications·2021
Same author

Pathological drivers of neurodegeneration in suspected non-Alzheimer's disease pathophysiology.

Alzheimer's research & therapy·2021
Same author

Hippocampal subfield pathologic burden in Lewy body diseases vs. Alzheimer's disease.

Neuropathology and applied neurobiology·2020
Same author

The differing pathophysiologies that underlie COVID-19-associated perniosis and thrombotic retiform purpura: a case series.

The British journal of dermatology·2020
Same author

Comparison of sporadic and familial behavioral variant frontotemporal dementia (FTD) in a North American cohort.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2020
Same author

Active lifestyles moderate clinical outcomes in autosomal dominant frontotemporal degeneration.

Alzheimer's & dementia : the journal of the Alzheimer's Association·2020

Semantic impairments disrupt reading by affecting orthographic and phonological processing. Semantic Dementia patients showed specific reading errors, unlike those with Alzheimer's or other dementias, suggesting not all semantic issues impact reading universally.

Area of Science:

  • Cognitive Neuroscience
  • Psycholinguistics
  • Neurology

Background:

  • Reading involves orthographic, phonological, and semantic processing components.
  • Traditional models treated these components independently.
  • Recent theories propose semantic representation is crucial for oral reading.

Purpose of the Study:

  • To investigate if semantic lexicon disruption affects orthographic and phonological processing in reading.
  • To examine specific oral reading error patterns predicted by semantic deterioration.
  • To compare reading difficulties in Semantic Dementia versus Alzheimer's Disease and other neurodegenerative conditions.

Main Methods:

  • Assessed oral reading performance in patients with Semantic Dementia.
  • Compared reading patterns with patients diagnosed with Alzheimer's Disease, Frontotemporal Dementia, and Progressive Non-Fluent Aphasia.

Related Experiment Videos

  • Analyzed error types, focusing on regularity advantage and real vs. pseudoword reading differences.

    • Main Results:

    • Patients with Semantic Dementia exhibited predicted reading difficulties, including regularization errors and a reduced pseudoword advantage.
    • Patients with Alzheimer's Disease, Frontotemporal Dementia, and Progressive Non-Fluent Aphasia did not show these specific reading patterns.
    • Semantic impairment in Semantic Dementia correlated with disruptions in orthographic and phonological processing during reading.

    Conclusions:

    • Semantic deterioration can lead to specific disruptions in reading, affecting orthographic and phonological lexicons.
    • The findings support the hypothesis that semantic representation is essential for intact oral reading.
    • Not all forms of semantic impairment invariably disrupt the reading systems, as evidenced by differing patient group results.