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Time course of inwardly rectifying K(+) current reduction in glial cells surrounding ischemic brain lesions
H Köller1, M Schroeter, S Jander
1Department of Neurology, Heinrich-Heine-University, Moorenstrasse 5, P.O. Box 101007, D-40001D-40225, Düsseldorf, Germany. koeller@neurologie.uni-duesseldorf.de
Brain Research
|August 5, 2000
Abstract:
K(+) currents of activated glial cells surrounding ischemic infarcts are investigated using acutely dissociated cells from the periinfarct area after permanent middle cerebral artery occlusion in rats. Inwardly rectifying K(+) currents (K(IR)) were markedly reduced in cells neighboring infarcts with maximal alteration at day 3 after infarct followed by a partial recovery. This reduction of glial K(IR) currents may contribute to the functional disturbances in the periinfarct area.