More cerebellar granule cells following prenatal low-dose X-irradiation

It was the aim of this study to estimating and comparing the total number of granule and Purkinje cells in the cerebellum of 180-day-old mice following a prenatal low-dose X-irradiation (50 cGy) at day 13 of gestation. Using the optical fractionator we found an expected, significant decrease of the total number of Purkinje cells (-21.1%; P=0.041) and a surprising, significant increase of the total number of granule cells (+23.1%; P=0.026) if comparing prenatally irradiated with sham-irradiated mice. The possible molecular basis of these seemingly paradoxical results is discussed.