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Ascorbic acid supplementation does not lower plasma lipoprotein(a) concentrations.

J L Jenner1, P F Jacques, L J Seman

  • 1Lipid Metabolism Laboratory, Jean Mayer USDA Human Nutrition Research Center on Aging at Tufts University, Boston, MA 02111, USA.

Atherosclerosis
|August 5, 2000
PubMed
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Ascorbic acid supplementation did not significantly alter lipoprotein(a) [Lp(a)] levels in healthy adults. This study found no effect of 1 g/day ascorbic acid on Lp(a) concentrations over 8 months.

Area of Science:

  • Cardiovascular Health
  • Nutritional Science
  • Biochemistry

Background:

  • Elevated lipoprotein(a) [Lp(a)] is a risk factor for premature coronary heart disease (CHD).
  • Lp(a) is composed of low-density lipoprotein (LDL) with attached apolipoprotein (apo) (a).
  • Ascorbic acid (vitamin C) is hypothesized to potentially reduce Lp(a) levels.

Purpose of the Study:

  • To investigate the efficacy of daily ascorbic acid supplementation in reducing plasma Lp(a) concentrations.
  • To evaluate the effect of 1 g/day ascorbic acid over an 8-month period.
  • To assess Lp(a) changes in a randomized, placebo-controlled, blinded study design.

Main Methods:

  • 101 healthy participants (aged 20-69 years) were enrolled.
  • Participants were randomized to receive either 1 g/day ascorbic acid or a placebo for 8 months.

Related Experiment Videos

  • Plasma Lp(a) concentrations were measured at baseline and after 8 months.

    • Main Results:

    • No significant difference in plasma Lp(a) levels was observed between the ascorbic acid and placebo groups at 8 months.
    • Baseline Lp(a) levels and changes over time did not differ significantly between groups.
    • Analysis of subjects with initially high Lp(a) (> or = 0.050 g/l) also showed no significant effect of supplementation.

    Conclusions:

    • Ascorbic acid supplementation at 1 g/day does not significantly impact plasma Lp(a) concentrations in healthy individuals.
    • The hypothesis that ascorbic acid reduces Lp(a) was not supported by this study's findings.
    • Further research may be needed to explore other potential interventions for managing Lp(a) levels.