Will "cerebral proteopathy" be a useful construct for discovering one drug that shows efficacy against multiple neurodegenerative diseases?

Experimental Assessment of Two Non-Contrast MRI Sequences Used for Computational Fluid Dynamics: Investigation of Consistency Between Techniques.

Cardiovascular engineering and technology·2020

Parahippocampal gyrus expression of endothelial and insulin receptor signaling pathway genes is modulated by Alzheimer's disease and normalized by treatment with anti-diabetic agents.

PloS one·2018

Cerebral [18 F]T807/AV1451 retention pattern in clinically probable CTE resembles pathognomonic distribution of CTE tauopathy.

Translational psychiatry·2016

Molecular systems evaluation of oligomerogenic APP(E693Q) and fibrillogenic APP(KM670/671NL)/PSEN1(Δexon9) mouse models identifies shared features with human Alzheimer's brain molecular pathology.

Molecular psychiatry·2015

Evidence that small molecule enhancement of β-hexosaminidase activity corrects the behavioral phenotype in Dutch APP(E693Q) mice through reduction of ganglioside-bound Aβ.

Molecular psychiatry·2014

Tauopathy PET and amyloid PET in the diagnosis of chronic traumatic encephalopathies: studies of a retired NFL player and of a man with FTD and a severe head injury.

Translational psychiatry·2014

Detecting dynamic pathways and risk indicators of resilience, vulnerability and stability in normally aging females and males: Integrating data-driven longitudinal and machine learning analyses.

Neurobiology of aging·2026

Individual Differences in Cognitive Aging Rodent Datasets (ID-CARD): A collaborative platform for behavioral analysis across the lifespan.

Neurobiology of aging·2026

Sex difference in brain reserve of working memory among older adults.

Neurobiology of aging·2026

Physical function moderates the relationship between white matter characteristics and gait variability during uneven terrain walking in aging.

Neurobiology of aging·2026

Input-output curves demonstrate motor cortex hyperexcitability associated with cognitive impairment in Alzheimer's disease.

Neurobiology of aging·2026

Age-related differences in resting and event-evoked ocular response dynamics.

Neurobiology of aging·2026

Deep Brain Stimulation: A Window Into the Neural Mechanisms of Latent Nystagmus.

Investigative ophthalmology & visual science·2026

A genetic and historical perspective on the origins of keratitis fugax hereditaria.

Acta ophthalmologica·2026

Noninvasive ventilation in patients with amyotrophic lateral sclerosis: Is home sleep apnea testing a useful tool for initiating noninvasive ventilation?

Multidisciplinary respiratory medicine·2026

Function within disorder: Small heat shock proteins use different functional regions to chaperone tau aggregation.

Protein science : a publication of the Protein Society·2026

Correlational Analysis of Qiming Granule with the CMKLR1-Centered Network and Systemic Inflammation via the Gut-Retina Axis in Diabetic Retinopathy.

Journal of visualized experiments : JoVE·2026

Domain-specific mutations in unc-6/Netrin differentially affect dorsal-ventral axon pathfinding in Caenorhabditis elegans.

Biology open·2026

Related Experiment Videos

Will "cerebral proteopathy" be a useful construct for discovering one drug that shows efficacy against multiple

Related Concept Videos

Experimental Assessment of Two Non-Contrast MRI Sequences Used for Computational Fluid Dynamics: Investigation of Consistency Between Techniques.

Parahippocampal gyrus expression of endothelial and insulin receptor signaling pathway genes is modulated by Alzheimer's disease and normalized by treatment with anti-diabetic agents.

Cerebral [18 F]T807/AV1451 retention pattern in clinically probable CTE resembles pathognomonic distribution of CTE tauopathy.

Molecular systems evaluation of oligomerogenic APP(E693Q) and fibrillogenic APP(KM670/671NL)/PSEN1(Δexon9) mouse models identifies shared features with human Alzheimer's brain molecular pathology.

Evidence that small molecule enhancement of β-hexosaminidase activity corrects the behavioral phenotype in Dutch APP(E693Q) mice through reduction of ganglioside-bound Aβ.

Tauopathy PET and amyloid PET in the diagnosis of chronic traumatic encephalopathies: studies of a retired NFL player and of a man with FTD and a severe head injury.

Detecting dynamic pathways and risk indicators of resilience, vulnerability and stability in normally aging females and males: Integrating data-driven longitudinal and machine learning analyses.

Individual Differences in Cognitive Aging Rodent Datasets (ID-CARD): A collaborative platform for behavioral analysis across the lifespan.

Sex difference in brain reserve of working memory among older adults.

Physical function moderates the relationship between white matter characteristics and gait variability during uneven terrain walking in aging.

Input-output curves demonstrate motor cortex hyperexcitability associated with cognitive impairment in Alzheimer's disease.

Age-related differences in resting and event-evoked ocular response dynamics.

Deep Brain Stimulation: A Window Into the Neural Mechanisms of Latent Nystagmus.

A genetic and historical perspective on the origins of keratitis fugax hereditaria.

Noninvasive ventilation in patients with amyotrophic lateral sclerosis: Is home sleep apnea testing a useful tool for initiating noninvasive ventilation?

Function within disorder: Small heat shock proteins use different functional regions to chaperone tau aggregation.

Correlational Analysis of Qiming Granule with the CMKLR1-Centered Network and Systemic Inflammation via the Gut-Retina Axis in Diabetic Retinopathy.

Domain-specific mutations in unc-6/Netrin differentially affect dorsal-ventral axon pathfinding in Caenorhabditis elegans.

Related Experiment Videos

Will "cerebral proteopathy" be a useful construct for discovering one drug that shows efficacy against multiple...

Related Concept Videos

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Will "cerebral proteopathy" be a useful construct for discovering one drug that shows efficacy against multiple