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Changes in 5-HT(7) serotonin receptor mRNA expression with aging in rat brain
R Kohen1, D E Heidmann, J Anthony
1VA Puget Sound Health Care System, Geriatric Research, Education and Clinical Center, GRECC-182B, Seattle, WA 98108, USA. ruko@u.washington.edu
Brain Research. Molecular Brain Research
|August 5, 2000
Abstract:
We examined 5-HT(7) receptor mRNA expression with in situ hybridization histochemistry in the brains of young (3 months), middle-aged (12 months) and old rats (24 months). In the ventral CA3 area of the hippocampus 5-HT(7) mRNA expression is reduced by approximately 30% between young and middle age without further decline between middle and old age. In other brain areas 5-HT(7) mRNA expression is unaffected by age.