Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Recirculatory and sessile CD4+ T lymphocytes differ on CD45RC expression.

F Ramírez1, D Mason

  • 1Sir William Dunn School of Pathology, University of Oxford, Oxford, United Kingdom.

Journal of Immunology (Baltimore, Md. : 1950)
|August 5, 2000
PubMed
Summary

CD4+ T cell distribution varies across rat lymphoid organs. Memory phenotype cells (CD45RClow) are more common in Peyer's patches, while recirculating cells (CD45RChigh) show varied organ entry.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Evidence for the Higgs Boson Decay to a Z Boson and a Photon at the LHC.

Physical review letters·2024
Same author

Probing Small Bjorken-x Nuclear Gluonic Structure via Coherent J/ψ Photoproduction in Ultraperipheral Pb-Pb Collisions at sqrt[s_{NN}]=5.02  TeV.

Physical review letters·2024
Same author

Measurement of the top quark mass using a profile likelihood approach with the lepton + jets final states in proton-proton collisions at <math></math>.

The European physical journal. C, Particles and fields·2023
Same author

Observation of τ Lepton Pair Production in Ultraperipheral Pb-Pb Collisions at sqrt[s_{NN}]=5.02  TeV.

Physical review letters·2023
Same author

A search for decays of the Higgs boson to invisible particles in events with a top-antitop quark pair or a vector boson in proton-proton collisions at <math></math>.

The European physical journal. C, Particles and fields·2023
Same author

Measurement of the Dependence of the Hadron Production Fraction Ratios f_{s}/f_{u} and f_{d}/f_{u} on B Meson Kinematic Variables in Proton-Proton Collisions at sqrt[s]=13  TeV.

Physical review letters·2023

Area of Science:

  • Immunology
  • Cell Biology

Background:

  • CD4+ T cells are crucial for adaptive immunity.
  • Secondary lymphoid organs (SLOs) are key sites for immune responses.
  • Understanding T cell subset distribution is vital for immunology research.

Purpose of the Study:

  • To investigate the distribution of CD4+ T cell subsets in rat secondary lymphoid organs.
  • To characterize the phenotypes of recirculating and non-recirculating CD4+ T cells.
  • To determine how T cell subset composition varies between Peyer's patches, lymph nodes, and spleen.

Main Methods:

  • Flow cytometry to analyze CD4+ T cell phenotypes (CD45RC, Thy-1, L-selectin).
  • Homing experiments to track T cell recirculation.
  • Comparative analysis of T cell populations in Peyer's patches, lymph nodes, and spleen.

Related Experiment Videos

Main Results:

  • CD4+ T cell subsets are unequally distributed across rat SLOs.
  • Memory phenotype CD4+ T cells (CD45RClow) are more frequent in Peyer's patches (PP) and increase with age.
  • Recirculating CD4+ T cells are primarily CD45RChigh, with varying entry efficiency into different SLOs.
  • A non-recirculating CD4+ T cell population, predominantly CD45RClow, exists within SLOs.

Conclusions:

  • Rat secondary lymphoid organs exhibit distinct CD4+ T cell subset compositions.
  • Differences in SLO composition are due to varying ratios of recirculating and non-recirculating CD4+ T cells.
  • These T cell populations display distinct CD45RC phenotypes, influencing their distribution and function.