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New indications for antidepressants.

A F Schatzberg¹

¹Department of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Calif 94305-5548, USA.

The Journal of Clinical Psychiatry

|August 5, 2000

Summary

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Newer antidepressants, including selective serotonin reuptake inhibitors, are effective for anxiety disorders and other conditions beyond depression. Research supports their use in various mental health and behavioral health issues.

Area of Science:

Pharmacology
Psychiatry
Clinical Medicine

Background:

Second and third-generation antidepressants demonstrate broad efficacy.
Selective serotonin reuptake inhibitors (SSRIs) and other novel agents are increasingly recognized for diverse therapeutic applications.

Purpose of the Study:

To review new and potential indications for recently developed antidepressants.
To summarize supporting evidence for these expanded therapeutic uses.

Main Methods:

Literature review of controlled studies and FDA-approved indications.
Analysis of antidepressant efficacy across various psychiatric and behavioral disorders.

Main Results:

SSRIs and other newer antidepressants are FDA-approved for major depressive disorder, generalized anxiety disorder, bulimia nervosa, obsessive-compulsive disorder, social phobia, panic disorder, and posttraumatic stress disorder.

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Controlled studies indicate efficacy in premenstrual dysphoric disorder, borderline personality disorder, obesity, smoking cessation, and alcoholism.

Conclusions:

Novel antidepressants exhibit a wide range of applications beyond major depressive disorder.
Evidence supports the expanded use of these agents in treating various anxiety and behavioral health conditions.