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Hemoglobin substitute and cardiopulmonary bypass
X M Mueller1, H T Tevaearai, D Jegger
1Clinic for Cardiovascular Surgery, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland.
ASAIO Journal (American Society for Artificial Internal Organs : 1992)
|August 5, 2000
Summary
Diaspirin crosslinked hemoglobin (DCLHb) maintained oxygen consumption during cardiopulmonary bypass (CPB) in calves. Despite lower cardiac output, DCLHb increased arteriovenous oxygen content difference, preserving oxygen delivery.
Area of Science:
- Cardiovascular Physiology
- Biomedical Engineering
- Hemorrhage Management
Background:
- Cardiopulmonary bypass (CPB) necessitates blood substitution, impacting oxygen transport.
- The efficacy of diaspirin crosslinked hemoglobin (DCLHb) as a blood substitute during CPB is not well-established.
Purpose of the Study:
- To investigate the effects of DCLHb on oxygen exchange during CPB in an animal model.
- To compare DCLHb with hydroxyethyl starch (Haes) in maintaining oxygen delivery and consumption.
Main Methods:
- Six calves underwent 5 hours of CPB with intermittent blood exchange.
- Blood was substituted with either Haes (control) or DCLHb (3 calves each).
- Cardiac output (CO), arteriovenous oxygen content difference (Ca-vO2), and oxygen consumption (VO2) were measured.
Main Results:
- The DCLHb group exhibited significantly lower CO (p < 0.01) but a higher Ca-vO2 (p < 0.01) compared to the Haes group.
- Oxygen consumption (VO2) remained comparable between groups (p = 0.52).
- DCLHb facilitated preserved oxygen consumption despite reduced cardiac output.
Conclusions:
- DCLHb effectively maintains oxygen consumption during CPB in this calf model.
- The mechanism involves an increased arteriovenous oxygen content difference, compensating for reduced cardiac output.
- DCLHb shows potential as a blood substitute in CPB settings.