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Controlled release from a composite silicone/hydrogel membrane.

Z Hu1, C Wang, K D Nelson

  • 1University of North Texas, Denton 76203, USA.

ASAIO Journal (American Society for Artificial Internal Organs : 1992)
|August 5, 2000
PubMed
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Researchers developed a silicone rubber (SR) composite gel with N-isopropylacrylamide (NIPA) hydrogel particles. This material demonstrates temperature-dependent drug release, showing promise for wound dressings.

Area of Science:

  • Biomaterials Science
  • Polymer Chemistry
  • Drug Delivery Systems

Background:

  • Silicone rubber (SR) has limitations in drug uptake and release.
  • Hydrogel particles offer potential for controlled release applications.

Purpose of the Study:

  • To enhance the drug delivery capabilities of silicone rubber.
  • To investigate the properties of SR composite gels incorporating N-isopropylacrylamide (NIPA) hydrogel particles.

Main Methods:

  • NIPA hydrogel particles were blended with uncured SR.
  • The composite mixture was cast and cured to form a 1 mm thick membrane.
  • Brilliant blue was used as a model drug to study uptake and release kinetics.

Main Results:

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  • The SR/NIPA composite gel exhibited water absorption capacity close to its dry weight.
  • Drug release was temperature-dependent, being low at T >= 34°C and high at T < 34°C.
  • Pulsed drug release was achieved by switching temperatures between 20°C and 39°C.

    • Conclusions:

    • The SR/NIPA composite gel shows tunable drug release properties based on temperature.
    • Optimal NIPA composition (75-87% by volume) facilitates an interconnected network for drug diffusion.
    • The developed composite gel is a promising candidate for wound dressing applications and other uses.