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Epithelial calcium channel: gate-keeper of active calcium reabsorption
J G Hoenderop1, D Müller, M Suzuki
1Department of Cell Physiology, University of Nijmegen, The Netherlands.
Current Opinion in Nephrology and Hypertension
|August 5, 2000
Abstract:
The epithelial calcium channel present in the apical membrane of 1,25-dihydroxyvitamin D3-responsive nephron segments represents the first member of a new family of calcium channels. This review covers the distinctive properties of this highly calcium-selective channel and highlights the implications for our understanding of the process of calcium reabsorption.