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Parathyroid hormone-related peptide and Indian hedgehog
1Endocrine Unit, Massachusetts General Hospital, Boston 02114, USA. chungu@helix.mgh.harvard.edu
Current Opinion in Nephrology and Hypertension
|August 5, 2000
Abstract:
Normal endochondral bone development requires temporal and spatial coordination of various cell types. Parathyroid hormone-related peptide and Indian hedgehog interact with each other and form a feedback loop that plays a major role in this coordination. Defects in the signalling of either of the two molecules cause severe bone malformations.