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The effects of acid on bone
1Department of Medicine, University of Rochester School of Medicine, New York, USA. David_Bushinsky@URMC.Rochester.edu
Current Opinion in Nephrology and Hypertension
|August 5, 2000
Abstract:
Metabolic acidosis induces calcium efflux from bone and in the process buffers the additional hydrogen ions. Initially metabolic acidosis stimulates physicochemical mineral dissolution and then cell-mediated bone resorption. Acidosis increases activity of the bone resorbing cells, the osteoclasts, and decreases activity of the bone forming cells, the osteoblasts. Osteoblastic immediate early response genes are inhibited as are genes controlling matrix formation.