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Familial Mediterranean fever.

N J Kubik¹, J D Katz

¹Hamot Medical Center, Erie, Pennsylvania, USA.

American Journal of Orthopedics (Belle Mead, N.J.)

|August 5, 2000

Summary

Familial Mediterranean fever (FMF) is a genetic disorder causing painful attacks. Early consideration and colchicine treatment are key for managing FMF symptoms and preventing complications like amyloidosis.

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Area of Science:

Rheumatology
Genetics
Internal Medicine

Background:

Familial Mediterranean fever (FMF) is an inherited multisystemic inflammatory disorder.
Diagnosis is challenging due to the lack of simple confirmatory tests.
FMF presents with recurrent febrile attacks affecting various body systems.

Observation:

A 10-year-old boy experienced recurrent joint and abdominal pain, initially treated with naproxen and omeprazole.
A 51-year-old man presented with fever, cough, and joint/abdominal pain.
Both patients eventually had Familial Mediterranean fever considered in their differential diagnosis.

Findings:

Colchicine is the gold standard treatment for FMF, effectively reducing attack frequency and severity.
Continuous colchicine therapy can prevent or delay secondary amyloidosis, a serious FMF complication.
Naproxen and omeprazole provided only intermittent relief in one FMF case.

Implications:

Highlights the diagnostic challenges in FMF, particularly in pediatric cases.
Emphasizes the critical role of colchicine in managing FMF and preventing long-term sequelae.
Suggests the need for increased awareness of FMF among clinicians to ensure timely diagnosis and treatment.

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