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Coagulation and bleeding disorders: review and update.

D A Triplett1

  • 1Indiana University School of Medicine and Midwest Hemostasis and Thrombosis Laboratories, Ball Memorial Hospital, Muncie, IN 47303, USA.dtriplett@cami3.com

Clinical Chemistry
|August 6, 2000
PubMed
Summary

This review covers hemostasis, the process of blood clotting initiated by vascular injury. It details platelet function, coagulation tests, and various bleeding disorders, both inherited and acquired.

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Area of Science:

  • Hematology
  • Vascular Biology
  • Clinical Pathology

Background:

  • Hemostasis involves platelet adhesion and aggregation at vascular injury sites.
  • Platelet plug formation is stabilized by fibrinogen.
  • Disorders of hemostasis can be hereditary or acquired.

Purpose of the Study:

  • To review laboratory tests for evaluating coagulation.
  • To discuss hereditary and acquired disorders affecting hemostasis.

Main Methods:

  • Review of literature on hemostasis and coagulation testing.
  • Discussion of platelet function and coagulation pathways.
  • Categorization of bleeding disorders.

Main Results:

  • Key laboratory tests include prothrombin time, activated partial thromboplastin time, thrombin time, and platelet count.
  • Hereditary disorders involve platelet or coagulation protein deficiencies.
  • Acquired disorders include disseminated intravascular coagulation and circulating anticoagulants.

Conclusions:

  • Understanding hemostasis is crucial for diagnosing and managing bleeding disorders.
  • Laboratory tests are essential for assessing coagulation function.
  • Both inherited and acquired conditions can impair hemostasis, leading to clinical bleeding.

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