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Fluoxetine in early poststroke depression: a double-blind placebo-controlled study
1Tour de Gassies, Neurorehabilitation Unit, Bruges, France. Wiartl@aol.com
Stroke
|August 6, 2000
Summary
Fluoxetine (FLX) effectively treats early poststroke depression (PSD) in hemiplegic patients, showing significant symptom improvement without major side effects. This offers a well-tolerated option for managing depression after stroke.
Area of Science:
- Neurology
- Psychiatry
- Clinical Pharmacology
Background:
- Poststroke depression (PSD) is common in hemiplegic patients, hindering recovery.
- Early intervention is crucial for functional outcomes.
Purpose of the Study:
- To assess the efficacy and safety of fluoxetine (FLX) for early PSD.
- To evaluate FLX's impact on depression, motor, cognitive, and functional recovery.
Main Methods:
- Multicenter, double-blind, placebo-controlled trial.
- Included hemiplegic patients with major depressive disorder (MADRS >19).
- Randomized to 20 mg/d fluoxetine (FLX) or placebo for 6 weeks.
Main Results:
- Fluoxetine significantly reduced Montgomery-Asberg Depression Rating Scale (MADRS) scores compared to placebo (P=0.05).
- Higher response rate (62.5% vs 33.3%) and greater mean MADRS decrease observed in the FLX group (P=0.02).
- No significant differences in motor, cognitive, or functional recovery; one patient had transient transaminase elevation.
Conclusions:
- Fluoxetine is effective and well-tolerated for early poststroke depression.
- Further studies are warranted for long-term efficacy and safety in this population.
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