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Increased eyelid pigmentation associated with use of latanoprost
1Department of Ophthalmology, Ulsan University School of Medicine, Asan Medical Center, Seoul, South Korea.
Purpose:
To report increased eyelid pigmentation as an adverse side effect associated with topical latanoprost.
Method:
Case report. A 62-year-old Korean woman with normal-tension glaucoma developed bilateral increased eyelid skin pigmentation 4 months after beginning treatment with latanoprost in both eyes. Clinical examinations were performed, and external photographs were taken.
Result:
Latanoprost was discontinued. Periodic examinations revealed that the eyelid skin pigmentation gradually diminished 1 month after the cessation of the drug, and decrease in pigmentation continued over 4 months of follow-up.
Conclusion:
An increase in eyelid skin pigmentation is a possible complication of topical latanoprost therapy, and the cessation of the drug can result in loss of induced pigmentation in humans.