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Updated: Aug 12, 2026
09:16
Meiotic Spindle Assessment in Mouse Oocytes by siRNA-mediated Silencing
Published on: October 11, 2015
Role of mitotic control in spermatogenesis
M R Gazvani1, E D Wilson, D H Richmond
1Department of Obstetrics and Gynaecology, Liverpool Women's Hospital, Liverpool, UK. m.r.gazvani@abdn.ac.uk
Fertility and Sterility
|August 6, 2000
Summary
Infertile men have higher rates of sex chromosome aneuploidies in both somatic cells and sperm compared to fertile donors. This suggests mitotic instability may contribute to unexplained oligozoospermia.
Area of Science:
- Human Genetics
- Reproductive Medicine
- Cytogenetics
Background:
- Sex chromosome aneuploidies can impact male fertility.
- Somatic cell aneuploidy may reflect broader genomic instability.
- Understanding aneuploidy in infertile men is crucial for diagnosis and treatment.
Purpose of the Study:
- To investigate the correlation between sex chromosome aneuploidies in somatic cells and spermatozoa.
- To compare aneuploidy rates in infertile men versus fertile donors.
- To explore the role of mitotic instability in unexplained oligozoospermia.
Main Methods:
- Prospective, controlled study involving 10 infertile men and 10 fertile donors.
- Karyotypically normal (46, XY) participants.
- Multicolor fluorescence in situ hybridization (FISH) on lymphocytes and spermatozoa for chromosomes X, Y, and 21.
Main Results:
- Significantly higher incidence of X, Y, and 21 aneuploidies in both lymphocytes and spermatozoa of infertile men.
- Positive correlation observed between somatic cell and sperm aneuploidy rates in all men.
- Aneuploidy rates were notably elevated in the infertile group.
Conclusions:
- Findings suggest a link between mitotic errors during spermatogenesis and unexplained oligozoospermia.
- Somatic cell aneuploidy may serve as an indicator of sperm aneuploidy.
- Mitotic instability is implicated as a potential factor in male infertility.
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