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Related Experiment Videos

Tissue polypeptide specific antigen (TPS) throughout normal pregnancy.

D Kassanos1, D Botsis, D Rizos

  • 1Second Department of Obstetrics and Gynecology, Aretaieion University Hospital, Athens, Greece.

Anticancer Research
|August 6, 2000
PubMed
Summary

Maternal serum TPS concentrations increase significantly during pregnancy, making this tumor marker reliable only in early pregnancy for monitoring breast cancer patients. Amniotic fluid TPS levels are higher than serum levels.

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Area of Science:

  • Reproductive biology
  • Oncology
  • Biochemistry

Background:

  • Tumor markers are crucial for cancer monitoring.
  • Pregnancy significantly alters physiological parameters.
  • Tissue polypeptide-specific antigen (TPS) is a tumor marker.

Purpose of the Study:

  • To measure TPS concentrations in maternal serum (MS) and amniotic fluid (AF) during pregnancy.
  • To assess the utility of TPS as a tumor marker for breast cancer patients during pregnancy.
  • To establish reference ranges for TPS in normal pregnancy.

Main Methods:

  • Informed consent was obtained from 140 participants, including pregnant women across trimesters, women at parturition, and non-pregnant controls.
  • Maternal serum and amniotic fluid samples were collected.

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  • TPS antigen levels were quantified using enzyme immunoassay (BEKI Diagnostics).

    • Main Results:

    • Maternal serum TPS concentrations increased significantly with gestational age (p < 0.0001).
    • Amniotic fluid TPS levels were markedly elevated compared to maternal serum (p < 0.0001) and declined significantly from the second trimester through labor.
    • TPS values during labor varied with delivery mode, being higher in vaginal deliveries than cesarean sections.

    Conclusions:

    • Pregnancy significantly influences maternal serum TPS levels.
    • TPS is a reliable tumor marker for breast cancer patients only during early pregnancy.
    • Further research is needed to understand TPS dynamics throughout pregnancy and its clinical implications.