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Detection of Low Copy Number Integrated Viral DNA Formed by In Vitro Hepatitis B Infection
11:14

Detection of Low Copy Number Integrated Viral DNA Formed by In Vitro Hepatitis B Infection

Published on: November 7, 2018

Coinfections with hepatitis g and/or c virus in hepatitis B-related chronic liver disease

C Pramoolsinsap1, V Sirikulchayanonta, W Busakorn

  • 1Department of Medicine, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand.

The Southeast Asian Journal of Tropical Medicine and Public Health
|August 6, 2000
PubMed

Insights

Hepatitis B virus (HBV)-related liver disease patients with concurrent Hepatitis G virus (HGV) or Hepatitis C virus (HCV) infections showed increased resistance to interferon therapy. HCV coinfection worsened liver disease severity and inhibited HBV replication.

Area of Science:

  • Hepatology
  • Virology
  • Immunology

Background:

  • Chronic Hepatitis B virus (HBV) infection affects millions globally, with coinfections potentially altering disease progression and treatment outcomes.
  • Hepatitis G virus (HGV) and Hepatitis C virus (HCV) are blood-borne viruses that can coinfect individuals with HBV.
  • Understanding the impact of HGV/HCV coinfections on HBV-related liver disease is crucial for optimizing patient management.

Purpose of the Study:

  • To investigate the prevalence and impact of HGV and/or HCV coinfections in patients with HBV-related chronic liver disease.
  • To assess the influence of HGV/HCV coinfection on HBV replication and liver disease severity.
  • To evaluate the response to interferon therapy in HBV patients with and without HGV/HCV coinfections.

Main Methods:

  • Studied 196 patients with HBV-related chronic liver disease and 100 HBsAg carriers for HGV/HCV coinfections.
  • Analyzed patient history for risk factors like blood transfusions and assessed serological markers (anti-HBe).
  • Measured serum HBV-DNA levels and evaluated liver histology before and after interferon treatment in a subset of patients.

Main Results:

  • Coinfections with HGV (10), HCV (5), or both (3) were found in 9.2% of HBV patients, with no coinfections in HBsAg carriers.
  • Coinfected patients had higher rates of blood transfusion exposure and were more frequently anti-HBe positive.
  • HCV coinfection was associated with lower HBV-DNA levels, higher pre-treatment histological scores, and significantly increased resistance to interferon therapy, with none achieving sustained HBV-DNA clearance.

Conclusions:

  • Parenteral exposure is a significant risk factor for HGV/HCV coinfection in chronic HBV infection.
  • HGV coinfection did not significantly impact chronic HBV infection.
  • HCV coinfection appears to inhibit HBV replication but exacerbates liver disease severity and hinders interferon treatment efficacy.

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