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Minocycline-induced pericardial effusion
C Christe1, F Ricou, R Stoller
1Department of Geriatrics, University Hospitals of Geneva, Switzerland.
The Annals of Pharmacotherapy
|August 6, 2000
Summary
Minocycline can cause a rare hypersensitivity reaction presenting as pericardial effusion and liver injury. This case highlights an unusual presentation without typical lung, skin, or joint symptoms.
Area of Science:
- Cardiology
- Hepatology
- Pharmacology
Background:
- Minocycline, a tetracycline antibiotic, is known for potential hypersensitivity reactions.
- These reactions commonly involve the lungs, skin, or joints.
- Autoimmune disorders are also associated with minocycline use.
Observation:
- A 39-year-old woman presented with dyspnea and chest pain after starting minocycline.
- Echocardiography revealed pericardial effusion.
- Laboratory findings included eosinophilia and acute mixed liver injury.
Findings:
- The patient's reaction was characterized by pericardial effusion and liver injury, without pulmonary, cutaneous, or articular involvement.
- Antinuclear antibody testing was negative, differentiating it from typical autoimmune presentations.
- The clinical presentation was attributed to a minocycline-induced hypersensitivity reaction.
Implications:
- This case underscores the potential for minocycline to induce rare hypersensitivity reactions with atypical manifestations.
- Clinicians should consider minocycline as a potential cause of pericardial effusion and liver injury, even in the absence of other common symptoms.
- Awareness of this unusual adverse effect is crucial for prompt diagnosis and management.
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