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Minocycline-induced pericardial effusion.

C Christe1, F Ricou, R Stoller

  • 1Department of Geriatrics, University Hospitals of Geneva, Switzerland.

The Annals of Pharmacotherapy
|August 6, 2000
PubMed
Summary
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Minocycline can cause a rare hypersensitivity reaction presenting as pericardial effusion and liver injury. This case highlights an unusual presentation without typical lung, skin, or joint symptoms.

Area of Science:

  • Cardiology
  • Hepatology
  • Pharmacology

Background:

  • Minocycline, a tetracycline antibiotic, is known for potential hypersensitivity reactions.
  • These reactions commonly involve the lungs, skin, or joints.
  • Autoimmune disorders are also associated with minocycline use.

Observation:

  • A 39-year-old woman presented with dyspnea and chest pain after starting minocycline.
  • Echocardiography revealed pericardial effusion.
  • Laboratory findings included eosinophilia and acute mixed liver injury.

Findings:

  • The patient's reaction was characterized by pericardial effusion and liver injury, without pulmonary, cutaneous, or articular involvement.
  • Antinuclear antibody testing was negative, differentiating it from typical autoimmune presentations.

Related Experiment Videos

  • The clinical presentation was attributed to a minocycline-induced hypersensitivity reaction.

    • Implications:

    • This case underscores the potential for minocycline to induce rare hypersensitivity reactions with atypical manifestations.
    • Clinicians should consider minocycline as a potential cause of pericardial effusion and liver injury, even in the absence of other common symptoms.
    • Awareness of this unusual adverse effect is crucial for prompt diagnosis and management.