Anatomic origin of P13 and P14 scalp far-field potentials

After median nerve stimulation, noncephalic or earlobe reference montages enable one to record over the scalp a well-defined, positive far-field response, which has been labeled the P14 or P13-P14 complex. It has been ascertained that this wave is generated in the caudal brainstem. Its use is reliable and sometimes mandatory in assessing a number of diseases that affect primarily the brainstem, such as multiple sclerosis or coma. Because of its complex shape as well as discrepant findings in the literature, it is still debated whether this potential is produced by a single or by multiple serial generators. The authors present these different views and summarize the different recording methods, while bearing in mind that some recording techniques are more suitable for routine purposes and others are preferred in selected cases, when more information regarding caudal brainstem function is required.