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Intraoperative mitomycin C in the treatment of pterygium
1Department of Ophthalmology, Kocaeli University, School of Medicine, Turkey.
Purpose:
To evaluate the effectiveness of intraoperative mitomycin C in preventing the recurrence of primary pterygium.
Methods:
In this prospective, randomized study, 38 eyes of 35 patients with primary pterygium were evaluated. In 19 eyes, the "bare sclera technique" combined with intraoperative application of 0.2 mg/mL (0.02%) mitomycin C for five minutes was performed (mitomycin C treated group). The other 19 eyes--taken as control group--underwent surgical excision alone. Statistics were analyzed using the Mann-Whitney U test and the Fischer's exact test.
Results:
Patients were 20-38 years of age. The mean age was 25.29 +/- 5.08 in the mitomycin C treated group and 25.00 +/- 5.19 in the control group. During the mean follow-up of 17.04 months (range, 12-36 months; SD = 5.89), 4 recurrences (21%) were observed in the mitomycin C treated group and 11 (57.8%) in the control group. The difference between the two groups was significant (p = 0.045). No postoperative complication was encountered in both groups except for recurrences.
Conclusion:
Intraoperative mitomycin C was found to be effective in preventing the recurrence of primary pterygium.
Insights
Intraoperative mitomycin C significantly reduces primary pterygium recurrence after surgery. This study found a lower recurrence rate in patients treated with mitomycin C compared to those who underwent surgery alone.
Area of Science:
- Ophthalmology
- Surgical Innovation
Background:
- Pterygium is a common eye condition that can lead to vision impairment.
- Recurrence after surgical excision remains a significant clinical challenge.
Purpose of the Study:
- To assess the efficacy of intraoperative mitomycin C in preventing primary pterygium regrowth.
Main Methods:
- A prospective, randomized study involving 35 patients (38 eyes) with primary pterygium.
- Comparison between the bare sclera technique with intraoperative mitomycin C application and surgical excision alone.
- Statistical analysis using Mann-Whitney U and Fischer's exact tests.
Main Results:
- The mitomycin C group showed a recurrence rate of 21% (4/19 eyes) versus 57.8% (11/19 eyes) in the control group.
- The difference in recurrence rates between the groups was statistically significant (p=0.045).
- No significant postoperative complications were noted in either group.
Conclusions:
- Intraoperative mitomycin C is an effective adjunct in preventing primary pterygium recurrence.
- The use of mitomycin C enhances surgical outcomes for pterygium excision.