Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Induction of tumor cell differentiation.

R A Flickinger1

  • 1Department of Biological Sciences, State University of New York at Buffalo 14260, USA.

Differentiation; Research in Biological Diversity
|August 10, 2000
PubMed
Summary

Cell proliferation with slower growth is needed for cell differentiation. This process may involve specific histone proteins playing a key role in the differentiation pathway.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

TIMING OF INCORPORATION OF TRITIATED NUCLEOSIDES INTO DNA AND RNA OF EMBRYONIC CELLS OF RANA PIPIENS.

Development, growth & differentiation·2023
Same author

Comparison of DNA and RNA synthesis in dorsal and ventral frog embryo ectoderm during gastrulation.

Wilhelm Roux' Archiv fur Entwicklungsmechanik der Organismen·2017
Same author

Nuclear DNA-like RNA of regions of developing frog embryos.

Wilhelm Roux' Archiv fur Entwicklungsmechanik der Organismen·2017
Same author

Transcriptional frequency and cell determination.

Journal of theoretical biology·2004
Same author

Cell proliferation and protein synthesis as initial factors in determination of axial polarity.

Development, growth & differentiation·2001
Same author

Hierarchical differentiation of multipotent progenitor cells.

BioEssays : news and reviews in molecular, cellular and developmental biology·1999

Area of Science:

  • Cell Biology
  • Molecular Biology
  • Biochemistry

Background:

  • Cell differentiation is a fundamental process in development and tissue maintenance.
  • Understanding the molecular mechanisms driving cell differentiation is crucial for regenerative medicine and disease research.

Purpose of the Study:

  • To investigate the role of cell proliferation and individual cell growth in cell differentiation.
  • To explore the potential involvement of histone proteins in the process of cell differentiation.

Main Methods:

  • The study proposes a theoretical framework based on existing biological principles.
  • It focuses on the relationship between cell division rates, protein synthesis, and histone expression patterns.

Main Results:

  • Cell proliferation with reduced total protein accumulation per cell is identified as a necessary, but not sufficient, condition for cell differentiation.
  • This proliferative state may promote the transcription and accumulation of specific histone variants (H1 and/or H1o) relative to core histones.

Conclusions:

  • The relative abundance of specific histone proteins, particularly H1 and H1o, may be critical for initiating and executing cell differentiation.
  • Further experimental validation is needed to confirm the precise role of these histones in the differentiation cascade.

Related Experiment Videos