Related Experiment Video
Updated: Sep 25, 2026

Histological Quantification to Determine Lung Fungal Burden in Experimental Aspergillosis
Published on: March 9, 2018
[Fungal pneumonia]
C P Heussel1, A J Ullmann, H U Kauczor
1Klinik und Poliklinik für Radiologie, Mainz. heussel@mail.uni-mainz.de
Abstract:
Concomitant with advances in medicine, involving the development and use of antibiotics, immunosuppressive drugs, organ/stem cell transplantation and pre-existing illnesses such as AIDS, the frequency of fungal infection has increased dramatically. These factors determine the susceptibility of the lung for an acute or chronic course of disease. Early detection, characterisation and follow-up of the pulmonary infiltrates is the major task of the radiologist. The correct timing to perform an investigation and adequate technique are an additional essential factor in this setting. Furthermore, radiological procedures support the clinicians in identifying the underlying micro-organism. The radiologist can suggest which micro-organism might cause the infiltrate. Certain findings and patterns can point to a specific causative agent, but experience, local epidemiology and clinical information are necessary for the differential diagnosis of infiltrates in long-term immunocompromised hosts. In addition, radiological techniques are useful in guiding interventions for identification of the underlying micro-organism or for therapeutical procedures. This review summarises useful radiological information of appearance and complications of fungal pneumonia.
Insights
Radiology is crucial for diagnosing fungal pneumonia in immunocompromised patients. Imaging helps detect pulmonary infiltrates, identify causative fungi, and guide treatment, improving patient outcomes.
Area of Science:
- Medical Imaging
- Infectious Diseases
- Pulmonology
Background:
- Increased incidence of fungal infections due to medical advancements like immunosuppression and organ transplantation.
- Immunocompromised individuals are highly susceptible to pulmonary fungal diseases.
- Pulmonary infiltrates are a common manifestation requiring early radiological assessment.
Purpose of the Study:
- To review the radiological findings and complications associated with fungal pneumonia.
- To highlight the radiologist's role in early detection and characterization of pulmonary infiltrates.
- To emphasize how imaging aids in identifying causative fungal agents and guiding clinical management.
Main Methods:
- Review of radiological literature on fungal pneumonia.
- Analysis of imaging patterns and their correlation with specific fungal pathogens.
- Discussion of the importance of imaging technique, timing, and clinical correlation.
Main Results:
- Specific radiological findings can suggest particular fungal species responsible for pneumonia.
- Radiology is essential for monitoring disease progression and complications.
- Imaging guides interventional procedures for diagnosis and therapy.
Conclusions:
- Radiological evaluation is indispensable for managing fungal pneumonia in immunocompromised hosts.
- Accurate interpretation of imaging findings, combined with clinical and epidemiological data, is key for differential diagnosis.
- Radiology plays a vital role from initial detection to therapeutic guidance in fungal pneumonia.
Related Concept Videos
Pneumonia I: Introduction
Risk Factors
Various factors influence the likelihood of developing pneumonia. Age plays a crucial role, with infants, children under two, and individuals over 65 at increased risk due to their...
Pneumonia II: Pathophysiology
Fungal Group Zygomycota
Atypical Pneumonia
Cryptococcal Meningitis
Pneumonia I: Introduction

