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Nutritional and insulin regulation of leptin gene expression
1Department of Human and Cultural Studies, Tezukayama Gakuin University, Sakai, Osaka, Japan. iritani@hcs.tezuka-gu.ac.jp
Current Opinion in Clinical Nutrition and Metabolic Care
|August 10, 2000
Abstract:
The leptin and lipogenic enzyme genes contain the common DNA sequences of binding sites for Sp1 proteins. These sites appear to be responsible for glucose/insulin stimulation and polyunsaturated fatty acid suppression. In rat adipose tissue leptin and lipogenic gene expression is similarly regulated by nutritional manipulation. Interestingly, leptin has the ability to down-regulate lipogenic enzyme expression.