Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Efficacy of the cation exchange resin, sodium polystyrene sulfonate, to decrease iron absorption.

G Shepherd1, W Klein-Schwartz, A H Burstein

  • 1Maryland Poison Center, Baltimore, USA. gsheph@parknet.pmh.org

Journal of Toxicology. Clinical Toxicology
|August 10, 2000
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Commentary: Future of Alzheimer's Disease Treatment: Combination Therapy and Precision Medicine.

The journal of prevention of Alzheimer's disease·2023
Same author

Hypersensitivity incidence after sugammadex administration in healthy subjects: a randomised controlled trial.

British journal of anaesthesia·2018
Same author

Development of Azeliragon, an Oral Small Molecule Antagonist of the Receptor for Advanced Glycation Endproducts, for the Potential Slowing of Loss of Cognition in Mild Alzheimer's Disease.

The journal of prevention of Alzheimer's disease·2018
Same author

Toxicity and clinical outcomes of paliperidone exposures reported to U.S. Poison Centers.

Clinical toxicology (Philadelphia, Pa.)·2014
Same author

Successful Desensitisation in a Patient with CRIM-Positive Infantile-Onset Pompe Disease.

JIMD reports·2013
Same author

Alternatives to standard acute in-patient care in England: differences in content of care and staff-patient contact.

The British journal of psychiatry. Supplement·2010
Same journal

Ingestion of high-dose buprenorphine by a 4 year-old child.

Journal of toxicology. Clinical toxicology·2005
Same journal

A reassessment of topical organic phosphorus insecticide exposures and permanent paralysis.

Journal of toxicology. Clinical toxicology·2005
Same journal

Methamphetamine toxicity secondary to intravaginal body stuffing.

Journal of toxicology. Clinical toxicology·2005
Same journal

Duodenal perforation after ibuprofen overdose.

Journal of toxicology. Clinical toxicology·2005
Same journal

Delayed dystonia following pimozide overdose in a child.

Journal of toxicology. Clinical toxicology·2005
Same journal

Pattern of acute poisonings in Mashhad, Iran 1993-2000.

Journal of toxicology. Clinical toxicology·2005
See all related articles

Sodium polystyrene sulfonate does not effectively bind iron in the gastrointestinal tract. This study found it ineffective for preventing iron absorption during an iron overdose in human volunteers.

Area of Science:

  • Toxicology
  • Pharmacokinetics
  • Gastroenterology

Background:

  • Iron overdose necessitates effective gastrointestinal decontamination methods.
  • Charcoal is ineffective at binding iron, highlighting the need for alternative agents.
  • Sodium polystyrene sulfonate was investigated for its potential iron-binding capacity.

Purpose of the Study:

  • To evaluate the efficacy of sodium polystyrene sulfonate in preventing iron absorption.
  • To assess the safety of sodium polystyrene sulfonate in the context of iron overdose.
  • To determine the pharmacokinetic impact of sodium polystyrene sulfonate on iron absorption.

Main Methods:

  • A prospective crossover trial involving six adult volunteers.
  • Administration of elemental iron (10 mg/kg) followed by sodium polystyrene sulfonate (30 g) or water (control).

Related Experiment Videos

  • Serial serum iron sampling to analyze pharmacokinetic parameters.

    • Main Results:

    • No statistically significant difference in time to peak serum iron concentration between treatment and control groups (p = 0.517).
    • A non-significant trend towards a smaller area-under-the-curve was observed with sodium polystyrene sulfonate.
    • Mean increase in serum iron above baseline was 298 mcg/dL (treatment) vs. 370 mcg/dL (control), not statistically significant (p = 0.44).

    Conclusions:

    • Sodium polystyrene sulfonate demonstrated no significant efficacy in reducing iron absorption.
    • The agent is not an effective method for gastrointestinal decontamination in cases of iron overdose.
    • Further research into effective iron-binding agents for overdose management is warranted.