Related Experiment Videos
Dynamic kinetic resolution of allylic alcohols mediated by ruthenium- and lipase-based catalysts
1Department of Chemistry, Division of Molecular and Life Science, Pohang University of Science and Technology, San 31 Hyojadong, Pohang, Kyungbuk 790-784, Korea.
Organic Letters
|August 10, 2000
Abstract:
An enzyme-metal combo reaction has been developed for the dynamic kinetic resolution of allylic alcohols in which racemic substrates are transformed by a lipase and a ruthenium complex in the presence of an acyl donor to allylic acetates of high optical purity in over 80% yield.